Article
Polymerase delta interacting protein 2 sustains vascular structure and function.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2013
Sutliff Roy L, Hilenski Lula L, Amanso Angélica M, Parastatidis Ioannis, Dikalova Anna E, Hansen Laura, Datla Srinivasa Raju, Long James S, El-Ali Alexander M, Joseph Giji, Gleason Rudolph L, Taylor W Robert, Hart C Michael, Griendling Kathy K, Lassègue Bernard
Abstract excerpt
OBJECTIVE: On the basis of previous evidence that polymerase delta interacting protein 2 (Poldip2) increases reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (Nox4) activity in vascular smooth muscle cells, we hypothesized that in vivo knockdown of Poldip2 would inhibit reactive oxygen species production and alter vascular function. APPROACH AND RESULTS: Because homozygous Poldip2 deletion is...
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