Article
PHB2 Maintains the Contractile Phenotype of VSMCs by Counteracting PKM2 Splicing.
Circulation research - 28 Oct 2022
Jia Yiting, Mao Chenfeng, Ma Zihan, Huang Jiaqi, Li Wenqiang, Ma Xiaolong, Zhang Siting, Li Meihong, Yu Fang, Sun Yingying, Chen Jingzhou, Feng Juan, Zhou Yuan, Xu Qingbo, Zhao Ling, Fu Yi, Kong Wei
Abstract excerpt
BACKGROUND: Phenotypic transition of vascular smooth muscle cells (VSMCs) accounts for the pathogenesis of a variety of vascular diseases during the early stage. Recent studies indicate the metabolic reprogramming may be involved in VSMC phenotypic transition. However, the definite molecules that link energy metabolism to distinct VSMC phenotype remain elusive. METHODS: A carotid artery injury model was used to...
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