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Article

p22phox C242T Single-Nucleotide Polymorphism Inhibits Inflammatory Oxidative Damage to Endothelial Cells and Vessels.

Circulation - 14 Jun 2016

Meijles Daniel N, Fan Lampson M, Ghazaly Maziah M, Howlin Brendan, Krönke Martin, Brooks Gavin, Li Jian-Mei

Abstract excerpt

BACKGROUND: The NADPH oxidase, by generating reactive oxygen species, is involved in the pathophysiology of many cardiovascular diseases and represents a therapeutic target for the development of novel drugs. A single-nucleotide polymorphism, C242T of the p22(phox) subunit of NADPH oxidase, has been reported to be negatively associated with coronary heart disease and may predict disease prevalence. However, the...

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Identifiers

PMID: 27162237
DOI: 10.1161/CIRCULATIONAHA.116.021993
PMCID: PMC6485513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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