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Article

The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice.

Molecular and cellular biology - 15 May 2016

Kapitsinou Pinelopi P, Rajendran Ganeshkumar, Astleford Lindsay, Michael Mark, Schonfeld Michael P, Fields Timothy, Shay Sheila, French Jaketa L, West James, Haase Volker H

Abstract excerpt

Hypoxia-inducible factors 1 and 2 (HIF-1 and -2) control oxygen supply to tissues by regulating erythropoiesis, angiogenesis and vascular homeostasis. HIFs are regulated in response to oxygen availability by prolyl-4-hydroxylase domain (PHD) proteins, with PHD2 being the main oxygen sensor that controls HIF activity under normoxia. In this study, we used a genetic approach to investigate the endothelial PHD2/HIF...

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Identifiers

PMID: 26976644
DOI: 10.1128/MCB.01055-15
PMCID: PMC4859687

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