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Article

Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts.

PloS one - 1 Jan 2014

Brown David I, Lassègue Bernard, Lee Minyoung, Zafari Rostam, Long James S, Saavedra Harold I, Griendling Kathy K

Abstract excerpt

Polymerase-δ interacting protein 2 (Poldip2) is an understudied protein, originally described as a binding partner of polymerase delta and proliferating cell nuclear antigen (PCNA). Numerous roles for Poldip2 have been proposed, including mitochondrial elongation, DNA replication/repair and ROS production via Nox4. In this study, we have identified a novel role for Poldip2 in regulating the cell cycle. We used a...

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Identifiers

PMID: 24797518
DOI: 10.1371/journal.pone.0096657
PMCID: PMC4010529

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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