Article

Adjusted vascular contractility relies on integrity of progranulin pathway: Insights into mitochondrial function

2023-11-01

Abstract excerpt

<h4>Objective</h4> Cardiovascular disease (CVD) is a global health crisis and a leading cause of mortality. The intricate interplay between vascular contractility and mitochondrial function is central to CVD pathogenesis. The progranulin gene (GRN) encodes glycoprotein progranulin (PGRN), a ubiquitous molecule with known anti-inflammatory property. However, the role of PGRN in CVD remains enigmatic. In this study...

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Literature Corpus work: 92cf5aa0-a946-5589-93f4-c324e717f6d2
DOI: 10.1101/2023.10.27.564485

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