Article
Mitochondrial oxidative stress in aortic stiffening with age: the role of smooth muscle cell function.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2012
Zhou Rui-Hai, Vendrov Aleksandr E, Tchivilev Igor, Niu Xi-Lin, Molnar Kimberly C, Rojas Mauricio, Carter Jacqueline D, Tong Haiyan, Stouffer George A, Madamanchi Nageswara R, Runge Marschall S
Abstract excerpt
OBJECTIVE: Age-related aortic stiffness is an independent risk factor for cardiovascular diseases. Although oxidative stress is implicated in aortic stiffness, the underlying molecular mechanisms remain unelucidated. Here, we examined the source of oxidative stress in aging and its effect on smooth muscle cell (SMC) function and aortic compliance using mutant mouse models. METHODS AND RESULTS: Pulse wave...
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