Article
20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition.
American journal of physiology. Heart and circulatory physiology - 1 May 2016
Lakhkar Anand, Dhagia Vidhi, Joshi Sachindra Raj, Gotlinger Katherine, Patel Dhara, Sun Dong, Wolin Michael S, Schwartzman Michal L, Gupte Sachin A
Abstract excerpt
20-Hydroxyeicosatetraeonic acid (20-HETE) produced by cytochrome P-450 monooxygenases in NADPH-dependent manner is proinflammatory, and it contributes to the pathogenesis of systemic and pulmonary hypertension. In this study, we tested the hypothesis that inhibition of glucose-6-phosphate dehydrogenase (G6PD), a major source of NADPH in the cell, prevents 20-HETE synthesis and 20-HETE-induced proinflammatory...
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