Article
Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target.
Circulation - 22 Jun 2010
Archer Stephen L, Marsboom Glenn, Kim Gene H, Zhang Hannah J, Toth Peter T, Svensson Eric C, Dyck Jason R B, Gomberg-Maitland Mardi, Thébaud Bernard, Husain Aliya N, Cipriani Nicole, Rehman Jalees
Abstract excerpt
BACKGROUND: Excessive proliferation and impaired apoptosis of pulmonary artery (PA) smooth muscle cells (PASMCs) contribute to vascular obstruction in patients and fawn-hooded rats (FHRs) with PA hypertension (PAH). Expression and activity of mitochondrial superoxide dismutase-2 (SOD2), the major generator of H(2)O(2), is known to be reduced in PAH; however, the mechanism and therapeutic relevance of this are...
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