Article
Glucose-6-phosphate dehydrogenase deficiency decreases vascular superoxide and atherosclerotic lesions in apolipoprotein E(-/-) mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2006
Matsui Reiko, Xu Shanqin, Maitland Karlene A, Mastroianni Roberto, Leopold Jane A, Handy Diane E, Loscalzo Joseph, Cohen Richard A
Abstract excerpt
OBJECTIVE: Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway that is a major source of cellular NADPH. The purpose of this study was to examine whether G6PD deficiency affects vascular oxidants and atherosclerosis in high-fat fed apolipoprotein (apo) E(-/-) mice. METHODS AND RESULTS: G6PD-mutant mice whose G6PD activity was 20% of normal were crossbred with apoE(-/-) mice....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.