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Article

The mitochondrial protease ClpP is a druggable target that controls VSMC phenotype by a SIRT1-dependent mechanism.

Redox biology - 1 Jul 2024

Paredes Felipe, Williams Holly C, Liu Xuesong, Holden Claire, Bogan Bethany, Wang Yu, Crotty Kathryn M, Yeligar Samantha M, Elorza Alvaro A, Lin Zhiyong, Rezvan Amir, San Martin Alejandra

Abstract excerpt

Vascular smooth muscle cells (VSMCs), known for their remarkable lifelong phenotypic plasticity, play a pivotal role in vascular pathologies through their ability to transition between different phenotypes. Our group discovered that the deficiency of the mitochondrial protein Poldip2 induces VSMC differentiation both in vivo and in vitro. Further comprehensive biochemical investigations revealed Poldip2's...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38823208
DOI: 10.1016/j.redox.2024.103203
PMCID: PMC11169483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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