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Article

PDIA1 acts as master organizer of NOX1/NOX4 balance and phenotype response in vascular smooth muscle.

Free radical biology & medicine - 1 Jan 2021

Fernandes Denise C, Wosniak João, Gonçalves Renata C, Tanaka Leonardo Y, Fernandes Carolina G, Zanatta Daniela B, de Mattos Ana Barbosa M, Strauss Bryan E, Laurindo Francisco R M

Abstract excerpt

Changes in vascular smooth muscle cell (VSMC) phenotype underlie disease pathophysiology and are strongly regulated by NOX NADPH oxidases, with NOX1 favoring synthetic proliferative phenotype and NOX4 supporting differentiation. Growth factor-triggered NOX1 expression/activity strictly depends on the chaperone oxidoreductase protein disulfide isomerase-A1 (PDIA1). Intracellular PDIA1 is required for VSMC...

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PMID: 33227407
DOI: 10.1016/j.freeradbiomed.2020.11.020

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