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Article

Acetylation of the cell-fate factor dachshund determines p53 binding and signaling modules in breast cancer.

Oncotarget - 1 Jun 2013

Chen Ke, Wu Kongming, Gormley Michael, Ertel Adam, Wang Jing, Zhang Wei, Zhou Jie, Disante Gabriele, Li Zhiping, Rui Hallgeir, Quong Andrew A, McMahon Steven B, Deng Haiteng, Lisanti Michael P, Wang Chenguang, Pestell Richard G

Abstract excerpt

Breast cancer is a leading form of cancer in the world. The Drosophila Dac gene was cloned as an inhibitor of the hyperactive epidermal growth factor (EGFR), ellipse. Herein, endogenous DACH1 co-localized with p53 in a nuclear, extranucleolar compartment and bound to p53 in human breast cancer cell lines, p53 and DACH1 bound common genes in Chip-Seq. Full inhibition of breast cancer contact-independent growth by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23798621
DOI: 10.18632/oncotarget.1094
PMCID: PMC3757249

Genes

DACH1
EGFR
RAD51

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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