Article

p53 status determines the epigenetic response to demethylating agents Azacitidine and Decitabine

2025-05-19

Abstract excerpt

5’-Azacitidine (Aza) and 5-Aza-2’-deoxycytidine (Dac) are widely used demethylating drugs that directly integrate into nucleic acids. They are frequently used interchangeably, surprisingly as their selectivity is unique from the other, with no predictors of response or clinical biomarkers to indicate drug preference. Using these drugs to induce demethylation, we combine DRIPc-Seq, Immunostaining, RNA-Seq and Mass...

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Literature Corpus work: c7420660-06c8-5057-a75e-9112ee1c597e
DOI: 10.1101/2025.05.19.654807

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