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Article

The cell fate determination factor DACH1 is expressed in estrogen receptor-alpha-positive breast cancer and represses estrogen receptor-alpha signaling.

Cancer research - 15 Jul 2009

Popov Vladimir M, Zhou Jie, Shirley L Andrew, Quong Judy, Yeow Wen-Shuz, Wright Jennifer A, Wu Kongming, Rui Hallgeir, Vadlamudi Ratna K, Jiang Jie, Kumar Rakesh, Wang Chenguang, Pestell Richard G

Abstract excerpt

The Dachshund (dac) gene, initially cloned as a dominant inhibitor of the Drosophila hyperactive EGFR mutant ellipse, encodes a key component of the cell fate determination pathway involved in Drosophila eye development. Analysis of more than 2,200 breast cancer samples showed improved survival by some 40 months in patients whose tumors expressed DACH1. Herein, DACH1 and estrogen receptor-alpha (ERalpha)...

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Source

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Identifiers

PMID: 19605405
DOI: 10.1158/0008-5472.CAN-08-3992
PMCID: PMC3244171

Genes

DACH1
PELP1
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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