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Article

The Cell Fate Determination Factor Dachshund Inhibits Androgen Receptor Signaling and Prostate Cancer Cellular Growth

7 Apr 2009

Abstract excerpt

Initially isolated as the dominant suppressor of the mutant epidermal growth factor receptor (ellipse), the Dachshund gene plays a key role in metazoan development regulating the Retinal Determination Gene Network. Herein, the DACH1 gene was expressed in normal prostate epithelial cells with reduced expression in human prostate cancer. DACH1 inhibited prostate cancer cellular DNA synthesis, growth in colony...

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Share to Estrogen and related hormone effects
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 19351840
DOI: 10.1158/0008-5472.can-08-3821

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