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The phylogenetic functional conservation of <i>Drosophila</i> Seven-In-Absentia (SINA) E3 ligase and its two human paralogs, SIAH1 and SIAH2, in <i>Drosophila</i> eye development

2020-04-30

Abstract excerpt

Seven-IN-Absentia (SINA) is the most downstream signaling gatekeeper identified thus far in the RAS/EGFR pathway that controls photoreceptor cell fate determination in Drosophila . Underscoring the central importance of SINA is its phylogenetic conservation in metazoans, with over 83% amino acid identities shared between Drosophila SINA and human SINA homologs (SIAHs). SIAH is a major tumor vulnerability in mult...

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Literature Corpus work
83697fcd-f02a-5a2b-9c47-e8c2bb7e31a0
DOI
10.1101/2020.04.28.067074
Open publication

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The phylogenetic functional conservation of <i>Drosophila</i> Seven-In-Absentia (SINA) E3 ligase and its two human paralogs, SIAH1 and SIAH2, in <i>Drosophila</i> eye developmentDOI 10.1101/2020.04.28.067074
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