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Article

EYA1 phosphatase function is essential to drive breast cancer cell proliferation through cyclin D1.

Cancer research - 15 Jul 2013

Wu Kongming, Li Zhaoming, Cai Shaoxin, Tian Lifeng, Chen Ke, Wang Jing, Hu Junbo, Sun Ye, Li Xue, Ertel Adam, Pestell Richard G

Abstract excerpt

The Drosophila Eyes Absent Homologue 1 (EYA1) is a component of the retinal determination gene network and serves as an H2AX phosphatase. The cyclin D1 gene encodes the regulatory subunits of a holoenzyme that phosphorylates and inactivates the pRb protein. Herein, comparison with normal breast showed that EYA1 is overexpressed with cyclin D1 in luminal B breast cancer subtype. EYA1 enhanced breast tumor growth...

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Source

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Identifiers

PMID: 23636126
DOI: 10.1158/0008-5472.CAN-12-4078
PMCID: PMC3755745

Genes

EYA1
SIX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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