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Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression

1 Aug 2022

Abstract excerpt

DBC1 has been characterized as a key regulator of physiological and pathophysiological activities, such as DNA damage, senescence, and tumorigenesis. However, the mechanism by which the functional stability of DBC1 is regulated has yet to be elucidated. Here, we report that the ubiquitination-mediated degradation of DBC1 is regulated by the E3 ubiquitin ligase SIAH2 and deubiquitinase OTUD5 under hypoxic stress....

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PMID: 35913115
DOI: 10.7554/elife.81247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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