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Cell Fate Determination Factor Dachshund Reprograms Breast Cancer Stem Cell Function

12 Oct 2010

Abstract excerpt

The cell fate determination factor Dachshund was cloned as a dominant inhibitor of the hyperactive epidermal growth factor receptor ellipse. The expression of Dachshund is lost in human breast cancer associated with poor prognosis. Breast tumor-initiating cells (TIC) may contribute to tumor progression and therapy resistance. Here, endogenous DACH1 was reduced in breast cancer cell lines with high expression of...

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PMID: 20937839
DOI: 10.1074/jbc.m110.148395

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