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Cell Fate Factor DACH1 Represses YB-1–Mediated Oncogenic Transcription and Translation

12 Dec 2013

Abstract excerpt

The epithelial-mesenchymal transition (EMT) enhances cellular invasiveness and confers tumor cells with cancer stem cell-like characteristics, through transcriptional and translational mechanisms. The mechanisms maintaining transcriptional and translational repression of EMT and cellular invasion are poorly understood. Herein, the cell fate determination factor Dachshund (DACH1), suppressed EMT via repression of...

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PMID: 24335958
DOI: 10.1158/0008-5472.can-13-2466

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