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DACH1 protects podocytes from experimental diabetic injury and modulates PTIP-H3K4Me3 activity

16 May 2021

Abstract excerpt

Dachshund homolog 1 (DACH1), a key cell-fate determinant, regulates transcription by DNA sequence-specific binding. We identified diminished Dach1 expression in a large-scale screen for mutations that convert injury-resistant podocytes into injury-susceptible podocytes. In diabetic kidney disease (DKD) patients, podocyte DACH1 expression levels are diminished, a condition that strongly correlates with poor...

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PMID: 33998601
DOI: 10.1172/jci141279

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