Article
The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5' HoxD genes during limb pattern formation.
Development (Cambridge, England) - 1 Dec 1995
Haramis A G, Brown J M, Zeller R
Abstract excerpt
Mutations in the murine limb deformity (ld) gene disrupt differentiation of the Apical Ectodermal Ridge (AER) and patterning of distal limb structures. However, initial outgrowth of the limb bud is not affected, suggesting that early and late functions of the AER are uncoupled. Similarly, activat...
Topics
- Animals
- Base Sequence
- DNA Primers
- Epithelium
- Extremities
- Feedback
- Fetal Proteins
- Fibroblast Growth Factor 4
- Fibroblast Growth Factors
- Formins
- Gene Expression Regulation, Developmental
- Genes, Homeobox
- Hedgehog Proteins
- Homeodomain Proteins
- Mesoderm
- Mice
- Mice, Inbred Strains
- Microfilament Proteins