Article
Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning.
Nature genetics - 1 Jul 2003
Khokha Mustafa K, Hsu David, Brunet Lisa J, Dionne Marc S, Harland Richard M
Abstract excerpt
During limb outgrowth, signaling by bone morphogenetic proteins (BMPs) must be moderated to maintain the signaling loop between the zone of polarizing activity (ZPA) and the apical ectodermal ridge (AER). Gremlin, an extracellular Bmp antagonist, has been proposed to fulfill this function and therefore be important in limb patterning. We tested this model directly by mutating the mouse gene encoding gremlin...
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