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Article

SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling.

Development (Cambridge, England) - 1 May 2011

Probst Simone, Kraemer Conradin, Demougin Philippe, Sheth Rushikesh, Martin Gail R, Shiratori Hidetaka, Hamada Hiroshi, Iber Dagmar, Zeller Rolf, Zuniga Aimée

Abstract excerpt

The essential roles of SHH in anteroposterior (AP) and AER-FGF signalling in proximodistal (PD) limb bud development are well understood. In addition, these morphoregulatory signals are key components of the self-regulatory SHH/GREM1/AER-FGF feedback signalling system that regulates distal progression of limb bud development. This study uncovers an additional signalling module required for coordinated progression...

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Source

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Identifiers

PMID: 21471156
DOI: 10.1242/dev.063966
PMCID: PMC3082298

Genes

SHH
GREM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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