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Article

Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFβ signals

26 May 2010

Abstract excerpt

In the developing axial skeleton, sequential sonic hedgehog (SHH) and bone morphogenetic protein (BMP) signals are required for specification of a chondrogenic fate in presomitic tissue. A similar paradigm is thought to operate in the limb, but the signals involved are unclear. To investigate the nature of these signals, we examined BMP action in mesenchymal populations derived from the early murine limb bud...

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Identifiers

PMID: 20501701
DOI: 10.1242/jcs.062901

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