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Article

Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1.

PLoS genetics - 1 Jan 2013

Farin Henner F, Lüdtke Timo H-W, Schmidt Martina K, Placzko Susann, Schuster-Gossler Karin, Petry Marianne, Christoffels Vincent M, Kispert Andreas

Abstract excerpt

Vertebrate limb outgrowth is driven by a positive feedback loop that involves Sonic hedgehog (Shh) and Gremlin1 (Grem1) in the posterior limb bud mesenchyme and Fibroblast growth factors (Fgfs) in the overlying epithelium. Proper spatio-temporal control of these signaling activities is required to avoid limb malformations such as polydactyly. Here we show that, in Tbx2-deficient hindlimbs, Shh/Fgf4 signaling is...

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Identifiers

PMID: 23633963
DOI: 10.1371/journal.pgen.1003467
PMCID: PMC3636256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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