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Article

Interactions between HOXD and Gli3 genes control the limb apical ectodermal ridge via Fgf10.

Developmental biology - 15 Jun 2007

Zakany Jozsef, Zacchetti Giovanna, Duboule Denis

Abstract excerpt

The development of the vertebrate limb is dependent upon two signaling centers, the apical ectodermal ridge (AER), which provides the underlying mesenchyme with essential growth factors, and the zone of polarizing activity (ZPA), the source of the Sonic hedgehog (SHH) product. Recent work involving gain and loss of function of Hox genes has emphasized their impact both on AER maintenance and Shh transcriptional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factor 10

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Source

Identifiers

PMID: 17467687
DOI: 10.1016/j.ydbio.2007.03.517

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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