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Article

Shh and Gremlin1 chromosomal landscapes in development and disease.

Current opinion in genetics & development - 1 Oct 2007

Zeller Rolf, Zuniga Aimée

Abstract excerpt

Two regulatory signals play major roles in digit patterning during vertebrate limb development, the SHH morphogen and the BMP antagonist Gremlin1. Their dynamic expression in limb buds is controlled by distant cis-regulatory elements embedded in unrelated neighboring genes, which has confused identification of the primary cause of different types of congenital limb malformations affecting mice and humans....

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Topics

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Share to Chromosomes, Human
Share to Gene Expression Regulation, Developmental
Share to SHH gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hedgehog Proteins

Share to Intercellular Signaling Peptides and Proteins

Share to Limb Deformities, Congenital

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Source

Identifiers

PMID: 17714931
DOI: 10.1016/j.gde.2007.07.006

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Shh and Gremlin1 chromosomal landscapes in development and disease.PMID 17714931Read ↗

Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog ( Shh).Semantic proximity Read ↗

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Alterations to the remote control of Shh gene expression cause congenital abnormalities.Semantic proximity Read ↗

Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly.Semantic proximity Read ↗

Anteroposterior patterning in the limb and digit specification: contribution of mouse genetics.Semantic proximity Read ↗

Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression.Semantic proximity Read ↗

Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling.Semantic proximity Read ↗

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