Article
Genetic polymorphisms of OCT-1 confer susceptibility to severe progression of primary biliary cirrhosis in Japanese patients.
Journal of gastroenterology - 1 Feb 2014
Ohishi Yuki, Nakamuta Makoto, Ishikawa Naoko, Saitoh Ohki, Nakamura Hitomi, Aiba Yoshihiro, Komori Atsumasa, Migita Kiyoshi, Yatsuhashi Hiroshi, Fukushima Nobuyoshi, Kohjima Motoyuki, Yoshimoto Tsuyoshi, Fukuizumi Kunitaka, Ishibashi Makoto, Nishino Takashi, Shirabe Ken, Taketomi Akinobu, Maehara Yoshihiko, Ishibashi Hiromi, Nakamura Minoru
Abstract excerpt
BACKGROUND: To identify the genetic factors involved in the pathogenesis of primary biliary cirrhosis (PBC), we focused on the organic cation transporter 1 (OCT1/SLC22A1), which is closely associated with phosphatidylcholine synthesis in hepatocytes. METHODS: We selected four (rs683369, rs2282143, rs622342 and rs1443844) OCT-1 single nucleotide polymorphisms (SNPs), and genotyped these SNPs using the TaqMan probe...