Article
A polymorphism in the integrin αV subunit gene affects the progression of primary biliary cirrhosis in Japanese patients.
Journal of gastroenterology - 1 May 2011
Inamine Tatsuo, Nakamura Minoru, Kawauchi Ayumi, Shirakawa Yayoi, Hashiguchi Hisae, Aiba Yoshihiro, Taketomi Akinobu, Shirabe Ken, Nakamuta Makoto, Hayashi Shigeki, Saoshiro Takeo, Komori Atsumasa, Yatsuhashi Hiroshi, Kondo Shinji, Omagari Katsuhisa, Maehara Yoshihiko, Ishibashi Hiromi, Tsukamoto Kazuhiro
Abstract excerpt
BACKGROUND: Accumulating evidence indicates that multiple genetic factors are involved in the pathogenesis of primary biliary cirrhosis (PBC). The aim of this study was to investigate whether polymorphisms of the integrin αV subunit gene (ITGAV), a component of integrin αVβ6, which plays an important role in the process of fibrosis, are associated with susceptibility to the onset and/or progression of PBC....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.