Article
Single-nucleotide polymorphism analysis of the multidrug resistance protein 3 gene for the detection of clinical progression in Japanese patients with primary biliary cirrhosis.
Hepatology (Baltimore, Md.) - 1 Sept 2008
Ohishi Yuki, Nakamura Minoru, Iio Naomi, Higa Shingo, Inayoshi Mao, Aiba Yoshihiro, Komori Atsumasa, Omagari Katsuhisa, Ishibashi Hiromi, Tsukamoto Kazuhiro
Abstract excerpt
UNLABELLED: Primary biliary cirrhosis (PBC) is a multifactorial disease in which genetic factors rather than environmental factors may predominantly contribute to the pathogenesis. In order to identify the genetic determinants of the disease severity and progression of PBC, we examined an association of seven tag single-nucleotide polymorphisms (SNPs) in the multidrug resistance protein 3 (MDR3/ABCB4) gene in 148...
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