Article
Association of genes involved in bile acid synthesis with the progression of primary biliary cirrhosis in Japanese patients.
Journal of gastroenterology - 1 Oct 2013
Inamine Tatsuo, Higa Shingo, Noguchi Fumie, Kondo Shinji, Omagari Katsuhisa, Yatsuhashi Hiroshi, Tsukamoto Kazuhiro, Nakamura Minoru
Abstract excerpt
BACKGROUND: Patients with primary biliary cirrhosis (PBC) exhibit a variety of clinical manifestations and patterns of disease progression. The aim of this study was to identify genetic determinants of PBC progression. METHODS: A total of 52 tag single nucleotide polymorphisms (SNPs) of 11 candidate genes involved in regulating bile acid synthesis were analyzed by polymerase chain reaction (PCR)-restriction...
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