Article
The association between bile salt export pump single-nucleotide polymorphisms and primary biliary cirrhosis susceptibility and ursodeoxycholic acid response.
Disease markers - 1 Jan 2014
Chen Rui-rui, Li Yuan-jun, Zhou Xin-min, Wang Lu, Xing Juan, Han Shuang, Cui Li-na, Zheng Lin-hua, Wu Kai-chun, Shi Yong-quan, Han Zhe-yi, Han Ying, Fan Dai-ming
Abstract excerpt
BACKGROUND: Primary biliary cirrhosis (PBC) is a chronic and progressive cholestasis liver disease. Bile salt export pump (BSEP) is the predominant bile salt efflux system of hepatocytes. BSEP gene has been attached great importance in the susceptibility of PBC and the response rate of ursodeoxycholic acid (UDCA) treatment of PBC patients. METHODS: In this study, TaqMan assay was used to genotype four variants of...
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