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Article

Pathophysiological analysis of primary biliary cirrhosis focusing on choline/phospholipid metabolism.

Liver international : official journal of the International Association for the Study of the Liver - 1 Mar 2015

Kohjima Motoyuki, Enjoji Munechika, Yada Ryoko, Yoshimoto Tsuyoshi, Nakamura Tsukasa, Fukuizumi Kunitaka, Fukushima Nobuyoshi, Murata Yusuke, Nakashima Manabu, Kato Masaki, Kotoh Kazuhiro, Shirabe Ken, Maehara Yoshihiko, Nakajima Atsushi, Nozaki Yuichi, Honda Akira, Matsuzaki Yasushi, Nakamuta Makoto

Abstract excerpt

BACKGROUND & AIMS: Injury to biliary epithelial cells caused by disorders in bile composition may be the initial step in the pathogenesis of primary biliary cirrhosis (PBC). We therefore examined choline/phospholipid metabolism in livers of patients with PBC. METHODS: Hepatic levels of mRNA encod...

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Source

Identifiers

PMID: 24620780
DOI: 10.1111/liv.12526

Genes

BHMT
PEMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24620780-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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