Article
Inter-individual variability in OCT1 expression and its relationship with OCT1 genotype in liver samples from a Korean population.
Drug metabolism and pharmacokinetics - 1 Jan 2012
Kim Min-Hye, Shin Ho Jung, Lim Su Jeong, Park Jung-Soon, Lee Sang-Seop, Song Im-Sook, Shin Jae-Gook
Abstract excerpt
To clarify inter-individual variation in the expression of organic cation transporter 1 (OCT1), the levels of OCT1 mRNA and protein from 65 human liver samples were examined by real-time PCR and Western blot analysis and were associated with OCT1 genotypes. The expression levels of OCT1 mRNA and protein in 65 liver samples of Korean origin were not normally distributed and varied by 23.6- and 15.9-fold,...
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