Article
Resistance to H-2-restricted but not to allo-H2-specific graft and cytotoxic T lymphocyte responses in lymphoma mutant.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1990
Ohlén C, Bastin J, Ljunggren H G, Foster L, Wolpert E, Klein G, Townsend A R, Kärre K
Abstract excerpt
The lymphoma mutant RMA-S escaped graft rejection after transplantation over a minor histocompatibility barrier, whereas it was rejected in H-2 allogeneic mice. The parental control line was rejected in both situations. The mutant, which had been selected against MHC class I molecules retained 5 to 10% of the wild-type H-2Db, Kb, and beta 2-microglobulin expression on the cell surface. It remained sensitive to...
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