Article
Transgenic mice expressing a soluble foreign H-2 class I antigen are tolerant to allogeneic fragments presented by self class I but not to the whole membrane-bound alloantigen.
Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1990
Arnold B, Messerle M, Jatsch L, Küblbeck G, Koszinowski U
Abstract excerpt
The properties of transmembrane and soluble transplantation antigens were compared with respect to the induction of tolerance and the selection of the T-cell repertoire. For this purpose, transgenic (H-2b x H-2d)F1 mice were constructed that carry integrated copies of a modified H-2Kk gene resulting in the secretion from various cell types including thymocytes of soluble H-2Kk molecules. Despite the presence of...
Topics
- Animals
- DNA
- H-2 Antigens
- Histocompatibility Antigens Class I
- Immune Tolerance
- Immunization
- Isoantigens
- Mice
- Mice, Transgenic
- Mutation