Article
Damage in B2m genes and DNA methylation of H-2 genes are involved in loss of expression of class I MHC products on the membrane of LR.4, a cell line derivative of the T-cell lymphoma L5178Y.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Jun 1992
Nava G, Ocadiz R, Ortega V, Alfaro G
Abstract excerpt
We have isolated an H-2 deficient cell line (LR.4) from the T-cell lymphoma L5178Y which grew without restrictions in the peritoneal cavity of different inbred strains of mice. The use of polyclonal anti-H-2 antiserum and complement indicated that LR.4 cells did not express class I determinants o...
Topics
- Animals
- Cell Division
- Cell Line
- Cell Membrane
- DNA, Neoplasm
- Genes, MHC Class I
- Leukemia L5178
- Methylation
- Mice
- Mice, Inbred Strains
- Mutation
- Species Specificity
- Transcription, Genetic