Article
The RMA-S lymphoma mutant; consequences of a peptide loading defect on immunological recognition and graft rejection.
International journal of cancer. Supplement = Journal international du cancer. Supplement - 1 Jan 1991
Ljunggren H G, Ohlén C, Höglund P, Franksson L, Kärre K
Abstract excerpt
Experiments with mutant cell lines have underscored the role for peptide in maintenance of the structure of major histocompatibility complex (MHC) class-I molecules. The class-I molecules act as receptors for antigenic and "self" peptides derived from degraded intracellular synthesized proteins....
Topics
- Animals
- Cell Line
- Cytotoxicity, Immunologic
- Graft Rejection
- H-2 Antigens
- Histocompatibility Antigens Class I
- Killer Cells, Natural
- Lymphoma
- Mice
- Mice, Inbred C57BL
- Mutation
- Neoplasm Transplantation
- Phenotype
- T-Lymphocytes, Cytotoxic