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Article

The RMA-S lymphoma mutant; consequences of a peptide loading defect on immunological recognition and graft rejection.

International journal of cancer. Supplement = Journal international du cancer. Supplement - 1 Jan 1991

Ljunggren H G, Ohlén C, Höglund P, Franksson L, Kärre K

Abstract excerpt

Experiments with mutant cell lines have underscored the role for peptide in maintenance of the structure of major histocompatibility complex (MHC) class-I molecules. The class-I molecules act as receptors for antigenic and "self" peptides derived from degraded intracellular synthesized proteins. The class-I/peptide trimeric complex is transported to the cell surface where it is scrutinized by cytotoxic T...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

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Source

Identifiers

PMID: 2066183
DOI: 10.1002/ijc.2910470711

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The RMA-S lymphoma mutant; consequences of a peptide loading defect on immunological recognition and graft rejection.PMID 2066183Read ↗

Empty MHC class I molecules come out in the cold.Semantic proximity Read ↗

Low temperature and peptides favor the formation of class I heterodimers on RMA-S cells at the cell surface.Semantic proximity Read ↗

Major histocompatibility complex (MHC)-encoded HAM2 is necessary for antigenic peptide loading onto class I MHC molecules.Semantic proximity Read ↗

Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter.Semantic proximity Read ↗

An endogenous antigenic peptide bypasses the class I antigen presentation defect in RMA-S.Semantic proximity Read ↗

Intracellular transport of class I MHC molecules in antigen processing mutant cell lines.Semantic proximity Read ↗

Immunization against tumor and minor histocompatibility antigens by eluted cellular peptides loaded on antigen processing defective cells.Semantic proximity Read ↗

Expression of medial class I histocompatibility antigens on RMA-S mutant cells.Semantic proximity Read ↗

Unique biochemical properties of a mutant MHC class I molecule, H-2Ksm1.Semantic proximity Read ↗

Mutant MHC class I molecules define interactions between components of the peptide-loading complex.Semantic proximity Read ↗

Peptide transporter-independent, stress protein-mediated endosomal processing of endogenous protein antigens for major histocompatibility complex class I presentation.Semantic proximity Read ↗

Gene required for normal MHC class II expression and function is localized to approximately 45 kb of DNA in the class II region of the MHC.Semantic proximity Read ↗

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