Threshold tolerance in H-2Kb-specific TCR transgenic mice expressing mutant H-2Kb: conversion of helper-independent to helper-dependent CTL.

doi:10.1093/intimm/4.12.1419

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Article

Threshold tolerance in H-2Kb-specific TCR transgenic mice expressing mutant H-2Kb: conversion of helper-independent to helper-dependent CTL.

International immunology - 1 Dec 1992

Auphan N, Jézo-Brémond A, Schönrich G, Hämmerling G, Arnold B, Malissen B, Schmitt-Verhulst A M

Abstract excerpt

To evaluate the role of the structure of the class I molecule and associated peptide(s) in intrathymic selection and tolerance, mice expressing as a transgene (tg) a TCR specific for the H-2Kb alloantigen were crossed with mice expressing the mutant class I molecule H-2Kbm1 or H-2Kbm8. In H-2k/k TCR tg mice (in a situation of exclusive positive selection), peripheral tg TCR expressing (Ti+) CD8+ T cells showed...

Topics

Animals
CD8 Antigens
Cell Differentiation
Cells, Cultured
Crosses, Genetic
H-2 Antigens
Immune Tolerance
Interleukin-2
Mice
Mice, Inbred C57BL
Mice, Inbred CBA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Mutation

Receptors, Antigen, T-Cell

T-Lymphocytes

T-Lymphocytes, Cytotoxic

Thymus Gland

Source

Open in PubMed

Identifiers

PMID: 1286065
DOI: 10.1093/intimm/4.12.1419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1286065-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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