Article
Molecular immunology of allograft rejection: insights from MHC mutants and crystal structure.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Jan 2000
DiSesa V J
Abstract excerpt
The molecular mechanisms of allograft recognition and rejection are not defined. Mice with mutations in the b allele of the H-2 K major histocompatibility complex (MHC) molecule and nonmutant parents reject skin grafts from each other. The amino acid sequences of the normal and mutant alleles are known and may be mapped on the crystal structure of the MHC molecule that has been worked out for HLA-A2. If we assume...
Topics
- Amino Acid Sequence
- Animals
- DNA Mutational Analysis
- Genes, MHC Class I
- Graft Rejection
- H-2 Antigens
- Humans
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutation