Role of major histocompatibility complex class I alpha 1/alpha 2 domain polymorphism and in vivo expression pattern in tumor resistance: studies with transgenic mice and lymphoma cell transfectants.

Abstract excerpt

The influence of major histocompatibility complex (MHC) class I molecules on target cell sensitivity and natural killer cell specificity was investigated. H-2b lymphoma cells grew progressively in syngeneic nontransgenic C57Bl/6 (B6) mice, but were rapidly rejected (within 24 h) in H-2Dd transgenic B6 mice (D8). Rejection required transgene expression in hematopoietic tissues, as revealed in experiments using...

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