Article
IL-10 converts mouse lymphoma cells to a CTL-resistant, NK-sensitive phenotype with low but peptide-inducible MHC class I expression.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1995
Salazar-Onfray F, Petersson M, Franksson L, Matsuda M, Blankenstein T, Kärre K, Kiessling R
Abstract excerpt
IL-10 has a variety of effects including: inhibition of monocyte MHC class II-dependent Ag presentation, Th1 cytokine production, and inhibition of T cell proliferation. Recently we have shown that IL-10 inhibits Ag presentation to human tumor-specific and allospecific CTL. In the present study we showed that transfection of the mouse lymphoma RMA (H-2b) with the IL-10 gene induced conversion to a RMA-S-like...
Topics
- Animals
- Antigen Presentation
- Cell Adhesion Molecules
- Cytotoxicity, Immunologic
- H-2 Antigens
- In Vitro Techniques
- Interleukin-10
- Killer Cells, Natural
- Lymphoma
- Mice