Article
NK-mediated elimination of mutant lymphocytes that have lost expression of MHC class I molecules.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2000
Kusunoki Y, Kyoizumi S, Honma M, Kubo Y, Ohnishi H, Hayashi T, Seyama T
Abstract excerpt
Mutant cells generated in vivo can be eliminated when mutated gene products are presented as altered MHC/peptide complexes and recognized by T cells. Diminished expression of MHC/peptide complexes enables mutant cells to escape recognition by T cells. In the present study, we tested the hypothesis that mutant lymphocytes lacking expression of MHC class I molecules are eliminated by autologous NK cells. In H-2b/k...
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