Article

HiCcompare: a method for joint normalization of Hi-C datasets and differential chromatin interaction detection

2017-06-08

Abstract excerpt

Changes in spatial chromatin interactions are now emerging as a unifying mechanism or-chestrating regulation of gene expression. Evolution of chromatin conformation capture methods into Hi-C sequencing technology now allows an insight into chromatin interactions on a genome-wide scale. However, Hi-C data contains many DNA sequence- and technology-driven biases. These biases prevent effective comparison of chromati...

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Literature Corpus work: 65156af2-7f8d-5419-ada6-22c2dda011ac
DOI: 10.1101/147850

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