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Article

Replication fork stability is essential for the maintenance of centromere integrity in the absence of heterochromatin.

Cell reports - 28 Mar 2013

Li Pao-Chen, Petreaca Ruben C, Jensen Amanda, Yuan Ji-Ping, Green Marc D, Forsburg Susan L

Abstract excerpt

The centromere of many eukaryotes contains highly repetitive sequences marked by methylation of histone H3K9 by Clr4(KMT1). This recruits multiple heterochromatin proteins, including Swi6 and Chp1, to form a rigid centromere and ensure accurate chromosome segregation. In the absence of heterochromatin, cells show an increased rate of recombination in the centromere, as well as chromosome loss. These defects are...

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Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23478021
DOI: 10.1016/j.celrep.2013.02.007
PMCID: PMC3652564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Replication fork stability is essential for the maintenance of centromere integrity in the absence of heterochromatin.PMID 23478021Read ↗

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