A genome-wide screen identifies genes required for centromeric cohesion.

doi:10.1126/science.1094220

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Article

A genome-wide screen identifies genes required for centromeric cohesion.

Science (New York, N.Y.) - 27 Feb 2004

Marston Adele L, Tham Wai-Hong, Shah Hiral, Amon Angelika

Abstract excerpt

During meiosis, two chromosome segregation phases follow a single round of DNA replication. We identified factors required to establish this specialized cell cycle by examining meiotic chromosome segregation in a collection of yeast strains lacking all nonessential genes. This analysis revealed Sgo1, Chl4, and Iml3 to be important for retaining centromeric cohesin until the onset of anaphase II. Consistent with...

Topics

Cell Cycle
Cell Cycle Proteins
Centromere
Chromosomal Proteins, Non-Histone
Chromosome Segregation
Chromosomes, Fungal
Cytoskeletal Proteins
Fungal Proteins
Gene Deletion
Genes, Fungal
Genome, Fungal
Green Fluorescent Proteins
Luminescent Proteins
Meiosis

Source

Open in PubMed

Identifiers

PMID: 14752166
DOI: 10.1126/science.1094220

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitosis

Mutation

Nondisjunction, Genetic

Nuclear Proteins