Article

ATR promotes genome instability via CENP-A eviction from centromeres under replication stress

2025-10-20

Abstract excerpt

<h4>ABSTRACT</h4> Replication stress leads to genome instability in part by promoting missegregation of chromosomes lacking centromeres. Yet the molecular mechanism linking replication stress to centromere dysfunction has remained elusive. Here, we show that sustained replication stress induces eviction of the histone H3 variant CENP-A. Displaced CENP-A relocalizes to nucleoli. This process is dependent on the DN...

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Literature Corpus work: 0606e33e-ab3b-59cb-97f1-e0ed5572836b
DOI: 10.1101/2025.10.20.683416

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