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Article

Centromere silencing and function in fission yeast is governed by the amino terminus of histone H3.

Current biology : CB - 14 Oct 2003

Mellone Barbara G, Ball Leslie, Suka Noriyuki, Grunstein Michael R, Partridge Janet F, Allshire Robin C

Abstract excerpt

BACKGROUND: Centromeric domains often consist of repetitive elements that are assembled in specialized chromatin, characterized by hypoacetylation of histones H3 and H4 and methylation of lysine 9 of histone H3 (K9-MeH3). Perturbation of this underacetylated state by transient treatment with histone deacetylase inhibitors leads to defective centromere function, correlating with delocalization of the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 14561399
DOI: 10.1016/j.cub.2003.09.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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